Study on Vitro Anti-HIV-1 Activity ofTaiqi PeiyuanGranules
10.3969/j.issn.1005-5304.2016.04.016
- VernacularTitle:太芪培元颗粒体外抗HIV-1病毒活性研究
- Author:
Xiulan MA
;
Jianping MA
;
Ying ZHANG
;
Aihemaiti ABUDUREYIMU
;
Jingru LI
;
Lin ZENG
;
Yongtang ZHENG
;
Liumeng YANG
;
Lixue MA
- Publication Type:Journal Article
- Keywords:
Taiqi Peiyuan Granules;
human immunodeficiency virus;
vitro antiviral activity;
immunologic mechanism
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(4):61-63
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the vitro anti-HIV-1 activity ofTaiqi Peiyuan Granules.MethodsMTT was used to detect cytotoxicity ofTaiqi Peiyuan Granules; cytopathy method was used to detect the inhibitory activity of Taiqi Peiyuan Granules on acute infection of HIV-1; HIV-1 p24 antigen ELISA detection was used to detect inhibitory activity ofTaiqi Peiyuan Granules for virus replication of HIV-1 acute infection cells, and count the medical therapeutic indexes.ResultsCC50ofTaiqi Peiyuan Granules in cytotoxicity test was 3.761±0.370 mg/mL; the EC50 of inhibition syncytial test was 0.454 5±0.204 6 mg/mL; the therapeutic index was between 5.84 and 12.97; p24 ofTaiqi Peiyuan Granules in inhibition experiments was 0.56±0.27 mg/mL, and the therapeutic index was between 5.30 and 8.74.ConclusionAnti-HIV-1 activity ofTaiqi Peiyuan Granules is relatively weak.
