Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics.
- Author:
Jason Yongha KIM
1
;
Jeong Hyun KIM
;
Byung Lae PARK
;
Charisse Flerida A PASAJE
;
Joon Seol BAE
;
Jong Sook PARK
;
An Soo JANG
;
Soo Taek UH
;
Yong Hoon KIM
;
Mi Kyeong KIM
;
Inseon S CHOI
;
Sang Heon CHO
;
Byoung Whui CHOI
;
Choon Sik PARK
;
Hyoung Doo SHIN
Author Information
- Publication Type:Original Article
- Keywords: Filamin A interacting protein 1; single nucleotide polymorphism; haplotype; asthma; aspirin exacerbated respiratory disease
- MeSH: Aspirin; Asthma; Contractile Proteins; Eating; Forced Expiratory Volume; Haplotypes; Humans; Hypersensitivity; Membranes; Microfilament Proteins; Negotiating; Polymorphism, Single Nucleotide
- From:Allergy, Asthma & Immunology Research 2013;5(1):34-41
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Aspirin exacerbated respiratory disease (AERD) results in a severe asthma attack after aspirin ingestion in asthmatics. The filamin A interacting protein 1 (FILIP1) may play a crucial role in AERD pathogenesis by mediating T cell activation and membrane rearrangement. We investigated the association of FILIP1 variations with AERD and the fall rate of forced expiratory volume in one second (FEV1). METHODS: A total of 34 common FILIP1 single nucleotide polymorphisms (SNPs) were genotyped in 592 Korean asthmatic subjects that included 163 AERD patients and 429 aspirin-tolerant asthma (ATA) controls. RESULTS: This study found that 5 SNPs (P=0.006-0.01) and 2 haplotypes (P=0.01-0.03) of FILIP1 showed nominal signals; however, corrections for the multiple testing revealed no significant associations with the development of AERD (P corr>0.05). In addition, association analysis of the genetic variants with the fall rate of FEV1, an important diagnostic marker of AERD, revealed no significant evidence (P corr>0.05). CONCLUSIONS: Although further replications and functional evaluations are needed, our preliminary findings suggest that genetic variants of FILIP1 might be not associated with the onset of AERD.
