A prospective comparison cohort study between baseline serum uric acid level and coronary artery disease in first-degree relatives and non-first-degree relatives of type 2 diabetes males
10.3760/cma.j.issn.1000-6699.2016.04.004
- VernacularTitle:男性2型糖尿病一级亲与非一级亲基线血尿酸水平与冠状动脉病变的前瞻性比较
- Author:
Xiujuan MA
;
Haili WANG
;
Guizhi YU
;
Xiuhua JIAO
;
Fengjie HAO
;
Lijing CAI
;
Zongqun ZHANG
- Publication Type:Journal Article
- Keywords:
Cohort study;
Serum uric acid;
Diabetes mellitus,type 2;
First-degree relatives;
Coronary artery disease
- From:
Chinese Journal of Endocrinology and Metabolism
2016;32(4):277-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between baseline serum uric acid and the severity of coronary artery disease ( CAD ) in the first-degree relatives or non-first-degree relatives of men with type 2 diabetes. Methods Three hundred and eighty-one men with negative coronary angiography for the first time were divided into diabetes and non-diabetes groups and followed-up for 5 years. The primary outcome was acute coronary syndrome suspected during subsequent 5 years, and the coronary angiography was conducted simultaneously. The severity of CAD was assessed by the coronary stenosis index ( CSI) and the number of coronary lesion vessels. Results In normal blood glucose group, serum uric acid was higher in the first-degree relatives of diabetics compared with non-first-degree relatives(P<0. 01), along with higher morbidity of CAD, CSI, and coronary lesion vessels (all P<0.01). Correlation analysis showed that CSI(r=0. 250, P=0. 041) and coronary lesion vessels(r=0. 252, P=0. 040) in non-diabetics group were associated with baseline levels of serum uric acid. Conclusion The elevation of serum uric acid was closely related to subsequent CAD, especially in first-degree relatives of male with type 2 diabetes, which could be used as an early indicator for CAD prediction.
