Effect of apraclonidine hydrochloride on acute introacular pressure rise after argon laser iridotomy.
- Author:
Chul HONG
1
;
Ki Yung SONG
;
Woo Hyung PARK
;
Young Ho SOHN
Author Information
- Publication Type:Original Article ; Clinical Trial ; Comparative Study ; Controlled Clinical Trial
- Keywords: apraclonidine hydrochloride; angle-closure glaucoma; argon laser irido-tomy (ALI); intraocula pressure(lOP)
- MeSH: Acute Disease; Adrenergic alpha-Agonists/*pharmacology; Adult; Aged; Clonidine/*analogs & derivatives/therapeutic use; Double-Blind Method; Female; Glaucoma, Angle-Closure/drug therapy/*surgery; Humans; Intraocular Pressure/*drug effects; Iris/drug effects/*surgery; *Laser Therapy; Male; Middle Aged; Postoperative Complications/prevention & control; Prospective Studies
- From:Korean Journal of Ophthalmology 1991;5(1):37-41
- CountryRepublic of Korea
- Language:English
- Abstract: To determine the effect of apraclonidine hydrochloride on the acute intraocular pressure (IOP) rise after argon laser iridotomy (ALI), a double-masked comparative study was carried out. Twenty-nine eyes (20 patients) with angle-closure glaucoma underwent ALI. Eighteen eyes were treated with apraclonidine, and the remainder received a placebo 1 hour before and immediately after ALI. The mean IOP increase in the apraclonidine group was lower than that in the placebo group at each postlaser interval (p < 0.01). Although the average value of the maximal increases of IOP after ALI in the apraclonidine group was 4 mmHg, that in the placebo group was 16 mmHg. In the placebo group, 27.3% (3 out of 11 eyes) experienced an IOP rise > or = 10 mmHg. However, that kind of IOP rise was not found in the apraclonidine group (0 out of 18 eyes) (p < 0.01). Ocular or systemic side effects were not found in a series of examinations in both groups. Therefore, apraclonidine proved to be effective in lowering the IOP rise after ALI.
