Research progress in multiple regulation pathways of STAT3 in cancer
10.3969/j.issn.1000-8179.2016.08.181
- VernacularTitle:STAT3的多重调控方式在肿瘤中的研究进展
- Author:
Yi YANG
;
Jie YUAN
;
Ruifang NIU
- Publication Type:Journal Article
- Keywords:
STAT3;
signal transduction;
GPCR;
TLR;
phosphorylation
- From:
Chinese Journal of Clinical Oncology
2016;43(8):352-357
- CountryChina
- Language:Chinese
-
Abstract:
The activation of the proto-oncogene STAT3 is strongly controlled under physiological conditions. However, obtained evi-dence revealed that STAT3 is persistently activated in cancer cells and contributes to cancer initiation and progression. Studies demon-strated the various functions of activated STAT3 in promoting cancer development and aggravation, including cancer cell proliferation, invasion and metastasis, drug resistance, epithelial-mesenchymal transition, regulation of the tumor microenvironment, and promo-tion of the self-renewal and differentiation of cancer stem cells. Canonically, STAT3 is regulated by signaling pathways mediated by cy-tokines and growth factors. Many studies determined that STAT3 was also regulated by G protein-coupled receptors, cadherin engage-ment, Toll-like receptors, microRNA, and acetylation. We summarized the recent developments in the research on the regulation of STAT3 activation.
