Bioinformatics analysis of the human MTERF1 gene promoter
10.16571/j.cnki.1008-8199.2016.04.003
- VernacularTitle:基于生物信息学分析人类线粒体转录终止因子1基因启动子
- Author:
Yongqin YANG
;
Meitao SUN
;
Yue LI
;
Yun WANG
;
Xiaojuan ZHANG
;
Wei XIONG
- Publication Type:Journal Article
- Keywords:
Bioinformatics;
Mitochondrial transcription ter-mination factor;
Promoter;
CpG island;
Tran-scription factor
- From:
Journal of Medical Postgraduates
2016;29(4):348-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective The proteins encoded by mitochondrial transcription termination factor 1 ( MTERF1) plays important roles in regulating the mitochondrial gene expression and oxidative phosphorylation .This study was to investigate the characteristics and regulation mechanisms of the human MTERF1 gene with bioinformatics tools . Methods Using online bioinformatics software and phylogenetic foot-printing, we analyzed the promoter distribution , GpG island, transcription factors , and binding sites of the human MTERF1 gene. Results The human MTERF1 gene was located on 7q21.2, with a full length of 7845 bp, consisting of 4 exons and 3 introns.There were at least 2 promoters in the 5′region of the gene.The core promoter of the MTERF1 gene was located between 1878 and 2447 bp, which played a key role in its transcription .An 812 bp CpG island was observed in the gene promoter region .In addi-tion, 26 transcription factor binding sites were found in the conserved promoter region of human and mouse homologous MTERF1 genes. Conclusion Gene promoter-related online bioinformatics software can improve the efficiency of human MTERF1 gene promoter resear-ches and provide significant information for the prediction of gene pro-moter function.
