Flurbiprofen Combined with Sufentanil for Analgesia After Han-uvulopalatopharyngoplasty Surgery
10.3969/j.issn.1009-6604.2016.04.017
- VernacularTitle:氟比洛芬酯联合不同剂量舒芬太尼用于改良悬雍垂腭咽成形术后镇痛
- Author:
Aizhu LIU
;
Lei GUAN
;
Weixuan SHENG
- Publication Type:Journal Article
- Keywords:
Han-uvulopalatopharyngoplasty;
Flurbiprofen;
Sufentanil;
Patient-controlled intravenous analgesia
- From:
Chinese Journal of Minimally Invasive Surgery
2016;16(4):351-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the analgesic efficiency and safety of patient-controlled intravenous analgesia ( PCIA) with both flurbiprofen and sufentanil after Han-uvulopalatopharyngoplasty ( H-UPPP) surgery. Methods Patients undergoing H-UPPP surgery ( n=60 ) were randomly divided into four groups with 15 cases in each group .They received PCIA after operation with a loading dose of 2 ml, lockout time of 15 minutes, background infusion rate of 2 ml/h and liquid volume of 100 ml.The PCIA formulation in each group was as follows:sufentanil 3.0 μg/h in group A;sufentanil 3.0 μg/h+flurbiprofen 4.0 mg/h in group B;sufentanil 2.0μg/h+flurbiprofen 4.0 mg/h in group C;sufentanil 1.0μg/h+flurbiprofen 4.0 mg/h in group D.The visual analogue scale (VAS) and Ramsay sedation scale were recorded at 2, 6, 12, 24, and 48 h after surgery (T1 -T5 time points).Patient pressing times and the adverse effects within 48 h after surgery were counted . Results The VAS scores of the group D were higher than those in the other three groups at T1 and T2 time points (P<0.05).The Ramsay scores of the group D were lower than those in the other three groups at T1 and T2 time points (P<0.05).The numbers of pressing times in the group D were more than those in the other three groups (P<0.05). Conclusion PCIA with both flurbiprofen 4.0 mg/h and sufentanil 2.0 μg/h is effective for postoperative analgesia after H-UPPP.
