The effects of BMP-2 expression in the related periodontal tissue on bone remolding of rapid tooth movement by resistance reduction and distration method
10.3969/j.issn.1001-3733.2016.01.011
- VernacularTitle:BMP-2在减阻牵张快速牙移动不同加力方式下的表达及对牙移动的影响
- Author:
Zaoxia PENG
;
Ning LI
;
Pei LI
;
Meijing LI
;
Lele YANG
;
Xi CHEN
;
Congbo MI
- Publication Type:Journal Article
- Keywords:
Reducing resistance and distraction;
Rapid tooth movement;
Bone morphogenetic protein 2 (BMP-2);
Bone remolding
- From:
Journal of Practical Stomatology
2016;32(1):53-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of bone morphogenetic protein 2(BMP-2)expression in the related periodontal tissue on bone remodeling under different distracting force during rapid tooth movement by resistance reduction and distraction. Methods:1 2 Beagle dogs were randomly divided into 4 groups as follows:5 d distraction,1 5 d distraction,1 5 d distraction and 1 0 d retaining and 1 5 d distraction and 90 d retaining.4 4 were distalized.6 teeth in each group were randomly assigned to re-sistance and distracting method,resistance and conventional method and conventional method,and there were 2 teeth in each group.Moving teeth models were prepared regularly.BMP-2 expression was examined by immunohistochemistry.Results:The BMP-2 positive expression of the 3 groups of different distraction schedule showed similar distribution area,and it reached peak at the end of 1 5-day distration,but the group of resistance and distracting method showed the maximum peak(P <0.05)and maximum tooth movement(P <0.01 ).In different stages of distraction,the positive expression in the group of resistance reduc-tion and conventional method was higher than in the group of conventional method but lower than the group of resistance reduction and extraction method(P <0.05).There was no significant difference in BMP-2 positive expression among 3 groups when retai-ning was 90 d(P >0.05).Conclusion:Resistance reduction with sustained strong distracting force can significantly increased the positive expression of BMP-2 and effectively accelerate new bone formation in periodontal tissue.
