Expression andsignificance of miR-155 in psoriasis vulgaris
10.3969/j.issn.1006-5725.2016.06.010
- VernacularTitle:microRNA-155在寻常型银屑病中的表达及意义
- Author:
Qi HE
;
Xianming PI
;
Quan SHI
;
Jiawen LI
;
Yingxiang YANG
;
Hongxiang CHEN
- Publication Type:Journal Article
- Keywords:
microRNA-155;
Psoriasis vulgaris;
TaqMan probe;
Interleukin-17
- From:
The Journal of Practical Medicine
2016;32(6):900-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toexplore the expression and significance of microRNA-155 (miR-155) in psoriasis vulgaris. Methods Areal-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) method with TaqMan probe technology was performed to detect miR-155 expression in skin lesion area and nonskinlesionalarea of 35 patients with psoriasis vulgaris , compared with that of 30 normal controls. The correlations among miR-155 expression, psoriasis area and severity index (PASI) score and Interleukin-17A(IL-17A)expression were studied. Results The expressions of miR-155 and IL-17A in lesional and non-lesionalgroups were higher than that of control group (all P < 0.01). Also expressions in lesional skin were higher than non-lesional skin (both P < 0.01). In skin lesion group, significant positive correlations existed betweenmiR-155 or IL-17A expression and PASI score as well as miR-155 and IL-17A expression (all P < 0.05). Conclusions Up-expression of miR-155 was relevant to psoriasis development , which is related withthe hyperfunctionof Th17 cells in psoriasis.
