Correlation of Ki-67 expression with MRS metabolism in low-and high-grade cerebral gliomas

VernacularTitle:高低级别脑胶质瘤的MRS代谢产物与Ki-67表达相关性研究
Author: Lianxue ZHANG ; Meng XU ; Benqiang YANG ; Wenyuan LIU ; Sen LIN ; Ziwen WANG ; Yang DUAN
Publication Type:Journal Article
Keywords: glioma; MRS; NAA; Cho; Ki-67
From: Chinese Journal of Clinical Oncology 2016;43(7):281-284
CountryChina
Language:Chinese
Abstract: objective:To investigate the relationship between magnetic resonance spectroscopy (MRS) metabolism and Ki-67 expres-sion in high-(HGG) and low-grade gliomas (LGG) by analyzing Ki-67 expression and HGG and LGG metabolites. Methods:We consid-ered 56 pathologically confirmed glioma cases in our hospital. The Ki-67 expression and the MRS metabolism parameters in the tu-mors were analyzed simultaneously. Results:The tumor solid value of Cho was positively correlated with the Ki-67 expression level (rs=0.714, P<0.05). By contrast, the Ki-67 expression level was negatively correlated with the tumor solid value of NAA (rs=?0.708, P<0.05) in 35 cases of the LGG group. The tumor solid value of Cho was also positively correlated with the Ki-67 expression level (rs=0.624, P<0.05). By comparison, the Ki-67 expression level was negatively correlated with the tumor solid value of NAA in the HGG group (rs=?0.769, P<0.05). Conclusion:The MRS metabolism was correlated with the Ki-67 expression in high-and low-grade gliomas.