Median effective plasma target concentration of propofol administered for lumbar surgery during inhala-tion-intravenous balanced anesthesia when BIS is 50
- VernacularTitle:腰椎手术静-吸复合麻醉脑电双频指数为50时的丙泊酚半数有效血浆靶浓度
- Author:
Rong ZOU
;
Fengzhen YAO
;
Shujuan JI
;
Jie GUO
;
Suyang CUI
- Publication Type:Journal Article
- Keywords:
Propofol;
Sevoflurane;
Remifentanyl;
Median effective plasma target concentra-tion;
Bispectral index
- From:
The Journal of Clinical Anesthesiology
2015;(12):1190-1192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the median effective plasma target concentration of propo-fol (Cp50 )needed for lumbar surgery during inhalation-intravenous balanced anesthesia when BIS is 50.Methods Patients aged 40-56 years,scheduled for vertebral pulp ectomy were included.Anesthe-sia were maintained by TCI of propofol,sevoflurane 0.5 MAC,remifentanyl 0.2 μg·kg-1 ·min-1 , and vecuronium 0.08 mg·kg-1 ·h-1 .The target plasma concentration of propofol was initially set at 1.8 μg/ml,and adjusted by the sequential up-and-down methods,based on BIS index.The Cp50 of propofol and its 95% confidence interval (CI)were calculated.Results Twenty-six patients were en-rolled in this study.The median effective plasma target concentration of propofol was 1.61 μg/ml (95%CI 1.52-1.70)μg/ml.Conclusion The Cp50 of propofol needed for maintaining the BIS index of 50 is 1.61 μg/ml during the anesthesia with 0.5 MAC of sevoflurane combined with remifentanyl in lumbar surgery.
