Expressions of Th1-Th2-Th17 cytokines in mice chronic viral myocarditis
10.3969/j.issn.1000-484X.2015.12.004
- VernacularTitle:Th1-Th2-Th17细胞因子在小鼠慢性心肌炎中的表达
- Author:
Xiaochun ZENG
;
Qing KONG
;
Weifeng WU
- Publication Type:Journal Article
- Keywords:
Cytokine;
Immune disorders;
Chronic viral myocarditis
- From:
Chinese Journal of Immunology
2015;31(12):1601-1604
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of Th 1-Th2-Th17 cytokines in the coxsackievirus B 3-induced mice chronic viral myocarditis(VMC).Methods:BALB/c mice were intraperitoneally(i.p) infected with increased CVB3 for establishing chronic VMC models.Control mice were treated with phosphate-buffered saline(PBS)i.p.Cardiac tissues were obtained 8 weeks after CVB3 in-jection,myocardial histopathologic changes were observed by HE and Masson staining .Th1-Th2-Th17 cytokines in plasma were detected by protein array technology , and their cardiac mRNA expressions were measured by RT-PCR.Results: Compared with the control group,levels of IL-2,IL-5,IL-10,IL-13,IL-17,IL-6,IL-22,IL-21 and TGF-βobviously increased in chronic VMC group (P all<0.05). Conclusion:The imbalance of Th1-Th2-Th17 cytokines may play an important roles in the pathogenesis of chronic VMC .
