The correlation study between the level of high-sensitivity C-reactive protein in acute phase of ischemic ;stroke and progressive stroke
10.3969/j.issn.1006-5725.2016.05.015
- VernacularTitle:缺血性脑卒中急性期超敏C－反应蛋白水平变化与进展性卒中的相关性
- Author:
Tao YAO
;
Mingshan REN
;
Huaiyu LI
- Publication Type:Journal Article
- Keywords:
Stroke;
Inflammation;
High-sensitivity C reactive protein;
Progressive stroke
- From:
The Journal of Practical Medicine
2016;32(5):735-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of the level of high-sensitivity C-reactive protein (Hs-CRP) in the acute phase of ischemic stroke and progressive stroke. Methods 101 patients with acute ischemic stroke were collected. Serum Hs-CRP of all patients were measured at 24 hours after admission , the onset of 48 hours, the onset of 72 hours by latex enhanced immune turbidity method. According to their serum Hs-CRP lev-els, the patients were divided into the group of Hs-CRP sustained growth (n = 35) and the group of non Hs-CRP sustained growth (n = 66). The NIHSS scores were assessed on two groups of patients , Logistic regression analysis was made to screen the related factors of Hs-CRP increase and the possible risky factors for progressive ischemic stroke. Results There was a significant difference of serum Hs-CRP level between the two groups (P <0.001). The incidence of progressive stroke in the group of Hs-CRP sustained growth was significantly higher than that in the group of non Hs-CRP sustained growth (χ2 = 32.710, P < 0.001). Logistic regression analysis showed blood glucose , white blood cell count , triglyceride level and NIHSS scores at admission were associated with sustained growth of Hs-CRP and the factors that they included Hs-CRP sustained growth , admission NIHSS scores, diabetes mellitus and pulmonary infection were regarded as independent risk factors. Conclusion The sustained growth of Hs-CRP in the acute phase of ischemic stroke is an independent predictor of progressive stroke.
