Efficacy of Acarbose in combination with life style modification on waist circumference in patients with impaired glucose tolerance

VernacularTitle:阿卡波糖联合调整生活方式改善糖调节受损人群腹围状况的研究
Author: Aidong SUN ; Qingping JING ; Shufen LI
Publication Type:Journal Article
Keywords: Acarbose; Impaired glucose tolerance (IGT); Waist circumference (WC); Islet β-cell function
From: Chinese Journal of Diabetes 2015;(12):1096-1098
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of acarbose on waist circumference (WC) in patients with IGR. Methods A total of 46 subjects with IGT (2 hPG>7.8 mmol/L) were selected in this study. All the subjects were given diet and exercise treatment for half a month and then treated with acarbose for 3 months in combination with life style modification. Self-paired method was adopted to compare islet βcell function and WC before and after the treatment. Results After acarbose treatment for 3 months ,islet βcell function were markedly improved. Insulin secretion of Fins and 2 hIns decreased ,early insulin secretion index (ΔI30/ΔG30 ) significantly increased ,and BMI and WC were reduced significantly (P<0.05) . Multiple regression analysis showed that there was correlation between WC and TG ,insulin resistance index (HOMA-IR) and islet β-cell function index (HOMA-β) (P< 0.05). Conclusion Acarbose in combination with life style modification can improve islet β-cell function in patients with IGR and reduce WC and abdominal fat accumulation as well.