Application of etomidate mixed with propofol during modified electroconvulsive therapy (MECT) in schizophrenics with hypertension
10.3969/j.issn.1006-5725.2015.23.040
- VernacularTitle:依托咪酯联合丙泊酚在精神障碍共患高血压患者无抽搐电休克治疗的应用
- Author:
Yijin OU
;
Min YE
;
Fengxing HU
- Publication Type:Journal Article
- Keywords:
Etomidate;
Propofol;
Hypertension;
Modified electroconvulsive therapy (MECT)
- From:
The Journal of Practical Medicine
2015;31(23):3935-3938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the treatment accomplishmentsand adverse effects of the mixed- or single-application of etomidate and propofol during modified electroconvulsive therapy (MECT) in schizophrenics with hypertension. Methods Ninety hospitalized schizophrenics with hypertension undergoing MECT were ran-domly assigned to 3 groups: Group EP(etomidate = 0.3 mg/kg and propofol = 1.0 mg/kg), Group E (etomi-date = 0.7 mg/kg) and Group P (propofol = 2.0 mg/kg). Changes of SBP, DBP and HR were recorded before anesthesia, after induction, electrical stimulation instantly and 5 min after electrical stimulation. The average pe-riods of epileptic seizure (ESD), postictal suppression index (PSI) and the adverse reactions were also recorded. Results The ESD and PSI scores were significantly higher in Group EP and Group E than those in Group P (P < 0.05). SBP and DBP in Group E were significantly higher at the electrical stimulation instant than those af-ter induction (P < 0.05). SBP and DBP in Group P were significantly lower after induction than those before anesthesia(P < 0.05). The injection pain of Group EP and Group E were lower than that of Group P(P < 0.05). No significant differences were found among 3 groups in the adverse reactions such as nausea/vomiting anddys-phoria.Conclusion The mixed liquor of etomidate and propofol can extend the time of seizure, reduce the nega-tive reaction of cardiovascular system and adverse reactions during MECT in schizophrenics with hypertension.
