Research progress of role of SOCS-3 in treating liver fibrosis
10.3969/j.issn.1001-1978.2015.12.005
- VernacularTitle:细胞因子信号转导抑制分子-3在肝纤维化中的作用及研究进展
- Author:
Zili ZHANG
;
Shifeng ZHAO
;
Wenxuan XU
;
Feng ZHANG
;
Li WU
;
Yin LU
;
Shizhong ZHENG
- Publication Type:Journal Article
- Keywords:
SOCS-3;
liver fibrosis;
mechanism;
signal path-way;
extracellular matrix;
hepatic stellate cell
- From:
Chinese Pharmacological Bulletin
2015;(12):1646-1651
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis occurs as compensatory responses to tis-sue repairing process in a wide range of chronic liver injures.It is characterized by excessive deposition of extracellular matrix (ECM)in liver tissues.The new discovery shows that suppres-sor of cytokine signaling (SOCS-3)is strictly associated with fi-brogenic progression of chronic liver diseases.Recent basic and clinical investigations also demonstrate that liver fibrogenesis is accompanied by SOCS-3,which critically determines the patho-
genesis and prognosis of liver fibrosis.This review summarizes current knowledge on SOCS-3 and the relationships between SOCS-3 and liver fibrosis.On the other hand,it also presents the different strategies that have been used in experimental mod-els to counteract excessive SOCS-3 and the role of SOCS-3 in the prevention and treatment of liver fibrosis.
