Effect of RAGE and its ligands on CD4 + T cells
10.3969/j.issn.1001-1978.2015.12.006
- VernacularTitle:RAGE 及其配体对 CD4＋T 细胞的作用研究进展
- Author:
Cui LYU
;
Zhaohua HOU
;
Yunbo WEI
;
Jinhong FENG
;
Yu DI
- Publication Type:Journal Article
- Keywords:
RAGE;
ligand;
CD4 + T cells;
proliferation;
mi-gration;
differentiation;
disease
- From:
Chinese Pharmacological Bulletin
2015;(12):1652-1655
- CountryChina
- Language:Chinese
-
Abstract:
RAGE (receptor for advanced glycation end products) is a multiligand receptor on the cell surface.Ligand-RAGE inter-actions activate several signal transduction pathways that propa-gate cellular oxidative stress and inflammatory response.RAGE expressed on the CD4 + T cells has been identified as a central transduction receptor which affects the activation,proliferation, migration and differentiation of the cells.In addition,blockade of RAGE suppressed the development of multiple immune-related
disorders mediated by CD4 + T cells.These studies highlight the importance of RAGE and its ligands for CD4 + T cells.This arti-cle briefly reviews the role of RAGE and its ligands on the prolif-eration,migration and differentiation of CD4 + T cells and sum-marizes the related research progress.
