Expression and clinical significance of CtBP2 in human esophageal squamous cell carcinoma
10.3969/j.issn.1000-8179.2015.22.005
- VernacularTitle:CtBP2在食管鳞状细胞癌中的表达及其临床意义
- Author:
Chengqi GUAN
;
Mingbing XIAO
;
Cuihua LU
;
Wenkai NI
;
Feng JIANG
;
Runzhou NI
- Publication Type:Journal Article
- Keywords:
esophageal squamous cell carcinoma;
CtBP2;
transcription factor;
immunohistochemistry
- From:
Chinese Journal of Clinical Oncology
2015;42(22):1081-1084
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of C-terminal binding protein 2 (CtBP2) in human esophageal carcinoma and its relationship with clinicopathological parameters and survival. Methods:The expression levels of CtBP2 in eight cases of fresh frozen specimens of esophageal squamous cell carcinoma (ESCC) and the adjacent esophageal tissues were detected by Western blot. Immuno-histochemistry was used to detect CtBP2 expression in 90 samples of ESCC tissues and adjacent non-tumor tissues. Based on patient in-formation and follow-up data, the correlation of CtBP2 expression with patients' clinicopathological characteristics and overall survival was further evaluated using Fisher's exact test and Kaplan-Meier method, respectively. Results: Immunohistochemistry and Western blot analysis showed that CtBP2 expression in tumor tissues was higher than that in adjacent non-tumor tissues. CtBP2 expression was significantly correlated with histologic grade (P=0.002) and depth (P=0.032). Kaplan-Meier analysis demonstrated that high CtBP2 ex-pression was correlated with a short survival time. Conclusion:CtBP2 expression was upregulated in ESCC tissues, indicating that it may play a role in the oncogenesis and development of ESCC.
