Research on clinical value of soluble triggering receptor expressed on myeloid cells-1 in the treatment and therapeutic effect evaluation of patients with an exacerbation of chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-1372.2015.09.012
- VernacularTitle:sTREM-1在AECOPD患者治疗及疗效评估中的临床价值研究
- Author:
Rao LIU
;
Faping ZHONG
;
Wenjun PEI
;
Tianli WANG
;
Zegang YANG
;
Yeqiang ZOU
- Publication Type:Journal Article
- Keywords:
Membrane glycoproteins/ME;
Receptors,immunologic/ME;
Pulmonary disease,chronic obstructive/ME
- From:
Journal of Chinese Physician
2015;17(9):1331-1334
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the treatment and therapeutic effect evaluation of patients with an exacerbation of chronic obstructive pulmonary disease.Methods The levels of serum sTREM-1,procalcitonin (PCT) and C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assay (ELISA) in 49 exacerbation of chronic obstructive pulmonary disease (COPD) subjects [acute exacerbation of chronic obstructive pulmonary disease (AECOPD) group],49 stable COPD subjects(sCOPD group) after treatment and 49 healthy volunteers as healthy control group.The levels of sTREM-1,PCT and CRP in different groups were compared and the relationship between the level of sTREM-1 in AECOPD and sCOPD groups,and PCT,and CRP was analyzed,respectively.Results The content of sTREM-1,PCT and CRP between different groups had significant difference(P ＜0.05).The level of sTREM-1 in both AECOPD and sCOPD groups was significantly positive correlated with PCT (P ＜ 0.05) and negative correlated with CRP (P ＞ 0.05).Conclusions For guiding the treatment and curative effect evaluation of patients with AECOPD,sTREM-1 has important clinical reference value.
