Molecular mechanism and application of translationally controlled tumor protein in tumor targeting ;therapy
10.3760/cma.j.issn.1673-422X.2015.10.009
- VernacularTitle:翻译控制肿瘤蛋白在肿瘤靶向治疗中的分子作用机制及应用
- Author:
Yujing HAN
;
Yilan LI
;
Xuelian NING
;
Huiying SUN
;
Chunshui ZHOU
- Publication Type:Journal Article
- Keywords:
DNA damage;
Drug resistance,neoplasm;
Translationally controlled tumor protein
- From:
Journal of International Oncology
2015;(10):753-755
- CountryChina
- Language:Chinese
-
Abstract:
Translationally controlled tumor protein (TCTP)is a small protein highly conserved in a variety of eukaryotic species.TCTP is overexpressed in various tumor cells and has been implicated in the regu-lation of cellular processes including apoptosis,DNA repair and drug resistance.By reviewing the recent pro-gress of TCTP research,TCTP is becoming an important regulator of DNA repair and a new molecular target for tumor therapy.
