Expression of CD38 and HLA -DR on CD +8 T cells in patients with chronic hepatitis B and HBV carriers
10.3760/cma.j.issn.1008-6706.2015.18.036
- VernacularTitle:慢性乙型肝炎患者及 HBV 携带者 CD ＋8 T 细胞表面活化分子 CD38和人类白细胞抗原-DR表达研究
- Author:
Xuefang CHEN
;
Yadi ZHOU
- Publication Type:Journal Article
- Keywords:
Hepatitis B,Chronic;
Immune activation;
CD38;
Human leukocyte antigen -DR
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(18):2836-2839
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of CD38 and HLA -DR on CD +8 T cells in patients with chronic hepatitis B and HBV carriers,and to disscuss the relation between immune activation and disease progression of HBV infection.Methods Thirty -two chronic hepatitis B patients receiving adefovir dipivoxil treatment,31 HBV carriers and 28 normal controls were collected.The counts of CD +4 and CD +8 T cells and the percentage of CD +8 CD +38 and CD +8 HLA -DR +T cells were tested by flow cytometry.HBV DNA and liver function were tested in the central laboratory of our hospital.Results The percentage of CD +8 CD +38 T cells in CHB patients was (58.4 ±12.7)%,and was higher than that in HBV carriers (46.8 ±8.5)% and normal controls (46.8 ±8.5)%,and decreased after adefovir dipivoxil treatment (34.2 ±9.4%)(F =8.27,P =0.000).The percentage of CD +8 CD +38 T cells in HBV carriers was (43.3 ±12.5)%,and was much higher than that in normal controls (9.8 ±5.7)%(F =13.48,P =0.000).The percentage of CD +8 HLA -DR + T cells in CHB patients was higher than that in normal controls,but similar to that in HBV carriers (37.1 ±11.3)%.CD +8 HLA -DR + T cells in CHB patients also decreased after adefovir dipivoxil treatment (P <0.05 ).Conclusion Our study demonstrates that activation of CD +8 T cells is increased in HBV infection but decreased by adefovir dipivoxil treatment.The percentages of CD +8 CD +38 and CD8 +HLA -DR +T are good markers for disease progression of HBV infection.
