Impact of -1304T→G polymorphism in MKK4 promoter on prognosis of colorectal cancer cases receiving adjuvant cheomotherapy
10.3969/j.issn.1006-5725.2015.18.016
- VernacularTitle:MKK4启动子多态－1304T→G对结直肠癌辅助化疗预后的影响
- Author:
Yisheng WEI
;
Minrui LUO
;
Zhihua LIANG
;
Guanghao KUANG
;
Chuyuan HONG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Adjuvant chemotherapy;
MKK4;
Polymorphism;
Prognosis
- From:
The Journal of Practical Medicine
2015;(18):2988-2991
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the impact of rs3826392 polymorphism in MKK4 promoter on prognosis of colorectal cancer cases (CRC) receiving adjuvant chemotherapy. Methods The associations between rs3826392 genotype of 203 CRC cases receiving adjuvant chemotherapy and clinicopathologic factors,overall survival (OS), disease free survival (DFS) were analyzed retrospectively. Results No association was found between rs3826392 genotype and clinicopathologic factors (P > 0.05). TG+GG genotype had better OS (P = 0.018) and DFS (P =0.019) when compared with TT genotype. Cox multivariate model showed rs3826392 TG+GG genotype remained independent favorable factor for OS(HR = 0.389;95%CI = 0.177-0.855) and DFS(HR=0.491;95%CI = 0.271-0.890) respectively. Conclusion -1304G variant genotypes (i.e., TG+GG) in rs3826392 may be the biomarker of better prognosis in CRC receiving adjuvant chemotherapy.
