Research progress on the function of kinesin-2 family proteins in model organisms
10.3969/j.issn.1005-4847.2015.05.015
- VernacularTitle:Kinesin-2 家族在模式生物中的功能研究进展
- Author:
Shanshan MIAO
;
Kuang YANG
;
Chengtian ZHAO
- Publication Type:Journal Article
- Keywords:
Kinesin-2;
Model organisms;
Cilia;
Zebrafish
- From:
Acta Laboratorium Animalis Scientia Sinica
2015;23(5):517-522
- CountryChina
- Language:Chinese
-
Abstract:
Kinesin-2 family proteins, including KIF3A, KIF3B, KIF3C and KIF17, are members of the kinesin superfamily motor proteins , which transport various proteins and vesicles in the cell and play diverse biological functions . Recently, studies on members of kinesin-2 family proteins suggest that they play fundamental roles during ciliary transport , whose defects can lead to abnormal cilia development , the major cause of human ciliopathies .In this review , we will sum-marize the functions of this motor protein family during ciliogenesis and focus mainly on their roles in the development of model organisms .
