Biocompatibility of a new titanium alloy containing copper
10.3969/j.issn.2095-4344.2015.34.013
- VernacularTitle:新型含铜钛合金的生物相容性
- Author:
Baorui REN
;
Jie LIU
;
Erlin ZHANG
;
Hui DONG
- Publication Type:Journal Article
- Keywords:
Material Testing;
Titanium;
Biocompatible Materials
- From:
Chinese Journal of Tissue Engineering Research
2015;(34):5473-5479
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Copper-titanium aloy has been fabricated in previous studies to improve the antibacterial property and biocompatibility of titanium materials. OBJECTIVE:With reference to the principle and experimental method specified by GB/T16886-ISO10993, to fuly and systematicaly assess the biocompatibility of copper-titanium aloy. METHODS:Based on the pre-experimental results, titanium aloy containing 10% copper was selected and subjected to oral mucosa stimulation experiment, skin stimulation test, acute systemic toxicity test, hemolytic test, prothrombin time test and dynamic coagulation test for biocompatibility evaluation. RESULTS AND CONCLUSION:The copper-titanium aloy has no oral mucous membrane irritation, no short-term systemic toxicity, no skin sensitization, and no hemolysis, indicating it has a good biocompatibility.
