Advance of microenvironment and the pathogenesis of hepatocellular carcinoma (HCC)
- VernacularTitle:微环境与肝癌发病机制的研究进展
- Author:
Yijiang DU
;
Changyi XIAO
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
microenvironment;
inflammation;
cirrhosis;
cell signaling;
DNA
- From:
Basic & Clinical Medicine
2015;(2):248-252
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma ( HCC) is a prevalent primary liver cancer that is driven by cumulative chan-ges in the hepatocyte genome which were influenced by the liver microenvironment .The tumor microenvironment is a dynamic system, including cancer cells, stroma, the extracellular matrix.tissue hypoxia, diet, gastrointestinal tract ( GIT) microflora and circulating microvesicles , The liver microenvironment plays a pivotal role in HCC tu-merigenesis , progression and therapeutic efficienry .The study of the HCC microenvironment will provide new in-sights into the mechanism of tumourigenesis and potential novel targets in the treatment of HCC .
