Research progress on disialoganglioside as target for immunotherapy of neuroblastoma
10.3760/cma.j.issn.2095-428X.2015.15.021
- VernacularTitle:以二唾液酸神经节苷脂为靶点对神经母细胞瘤行免疫治疗的研究进展
- Author:
Guodong SHI
;
Yongjun FANG
;
Xiang ZHOU
;
Kangjing XU
- Publication Type:Journal Article
- Keywords:
Neuroblastoma;
Ganglioside;
Immunotherapy
- From:
Chinese Journal of Applied Clinical Pediatrics
2015;30(15):1196-1198
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma(NB),the common extracranial solid tumor of childhood,is thought to derive from neural crest cells.In disialoganglioside (GD)2 is highly expressed on NB,whereas GD2 expression is weak and restricted to the central nervous system,peripheral pain fibers and skin melanocytes.Therefore,GD2 is an ideal antigen target for immunotherapy of NB.The research progress on GD2 as target for immunotherapy of NB was reviewed.
