Biological mechanisms and clinical significance of isocitrate dehydrogenase 1 mutation in glioma
10.3760/cma.j.issn.1673-422X.2015.11.011
- VernacularTitle:胶质瘤异柠檬酸脱氢酶1突变的生物学机制和临床意义
- Author:
Jiarun LI
;
Liu YANG
;
Geng GUO
- Publication Type:Journal Article
- Keywords:
Isocitrate dehydrogenase 1;
Mutation;
Glioma;
Tumor markers,biological;
Prognosis
- From:
Journal of International Oncology
2015;42(11):838-840
- CountryChina
- Language:Chinese
-
Abstract:
Isocitrate dehydrogenase 1 (IDH1), a key rate-limiting enzyme in tricarboxylic acid cycle,is found within the cytoplasm and peroxisomes.In recent years, IDH1 mutation is discovered in most gliomaand its large scale metabolites, 2-hydroxyglutarate, may be involved in tumor as potential carcinogens, and isshown to be closely related to better patients' survival as well.IDH1 mutation is anticipated to be a novel genet-ic biomarker which will guide the treatments of clinical glioma.
