Long noncoding RNAs:biological functions and applications in organ development and malignant tumors
10.3969/j.issn.1000-4718.2015.11.030
- VernacularTitle:长链非编码 RNAs 的生物功能及其与器官发育和恶性肿瘤的关系
- Author:
Mingjiao ZHANG
;
Yong WU
;
Minmin LI
- Publication Type:Journal Article
- Keywords:
Long noncoding RNAs;
Malignant tumor
- From:
Chinese Journal of Pathophysiology
2015;(11):2107-2112
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNAs( lncRNAs) are classified as transcripts >200 nucleotides in length with lit-tle or no evidence of protein-coding potential, and can regulate gene expression at various levels, including transcriptional regulation, posttranscriptional processing and so on.It has been widely involved in cell differentiation, individual develop-ment and other important life processes.Recent studies show lncRNA-related dysfunction plays critical roles in various dis-eases, indicating that lncRNA may serve as a new target for disease diagnosis and treatment.This review summarizes the functions of lncRNAs, including various modes of lncRNAs in regulating gene expression, the roles of lncRNAs in differen-tiation and development, and the connection between lncRNAs and malignant tumor.
