Simultaneous versus staged resection for synchronous rectal cancer liver metastasis
10.3969/j.issn.1000-8179.2015.21.903
- VernacularTitle:直肠癌同时性肝转移同期切除与分期切除比较
- Author:
Kemin JIN
;
Ming LIU
;
Xiaoluan YAN
;
Lijun WANG
;
Kun WANG
;
Quan BAO
;
Yi SUN
;
Hongwei WANG
;
Baocai XING
- Publication Type:Journal Article
- Keywords:
rectal neoplasm;
liver metastasis;
synchronous;
simultaneous hepatectomy;
staged hepatectomy;
complications;
prognosis
- From:
Chinese Journal of Clinical Oncology
2015;(21):1056-1062
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the safety and long-term survival of patients with synchronous rectal cancer liver metastasis, who received either simultaneous or staged resection to treat primary tumor and liver metastases. Methods:Clinicopathologic and peri-operative data were collected retrospectively from 54 patients with synchronous rectal cancer liver metastasis, who received both prima-ry and liver resections between January 2000 and April 2015 at Peking University Cancer Hospital. Routine follow-up was conducted. The safety and long-term survival of 19 patients who underwent simultaneous resection were compared with those of 35 patients who received staged resection. Results:The clinicopathologic data between the two groups were comparable. Postoperative Clavien-Dindo grades 1, 2, 3, and 4 complications were 10.5%(2/19), 31.6%(6/19), 5.3%(1/19), and 10.5%(2/19) for the simultaneous group, respec-tively, and 8.6%(3/35), 17.1%(6/35), 25.7%(9/35), and 0%(0/35) for the staged group correspondingly, which were not significantly different (P=0.093). However, the median postoperative hospital stay of the simultaneous group was significantly shorter than that of the staged group (14 days versus 25 days, P<0.001). The median postoperative overall survival (OS) and disease-free survival (DFS) be-tween these groups were not significantly different [not reached versus 39 months for OS, respectively (P=0.649);10 months versus 10 months for DFS, respectively (P=0.827)]. Conclusion:The postoperative complications in simultaneous resection group were not sig-nificantly increased compared with those in staged resection group for synchronous rectal cancer liver metastasis. The long-term results among the groups were similar.
