Hyperthyroid-associated EMA syndrome:four cases report and review of literature

VernacularTitle:甲状腺功能亢进症相关性EMA综合征四例报道并文献复习
Author: Bin LU ; Hongying YE ; Zhaoyun ZHANG ; Yehong YANG ; Jie WEN ; Xiaolong ZHAO ; Xi WU ; Yiming LI ; Renming HU ; Hong LIU
Publication Type:Journal Article
Keywords: Hyperthyroidism; EMA syndrome; Anterior tibial myxedema; Topical hormone therapy
From: Chinese Journal of Endocrinology and Metabolism 2015;(9):790-792
CountryChina
Language:Chinese
Abstract: [Summary] Four patients with hyperthyroid-associated exophthalmos, myxedema, acropachy ( EMA ) syndrome, including three male patients and one female patient were diagnosed with Graves′diseases and treated by 131 I therapy. Complaints of thyrotoxicosis were presented at the onset. Tibia myxedema and acropathy appeared, and eye symptoms aggravated in two patients after anti-thyroid drug therapy and 131 I therapy. Four cases were all given clobetasol propionate, miconazole nitrate, neomycin sulfate and urea cream alone or in combination with compound betamethasone local injection treatment, and three cases were given low-dose oral prednisone treatment. Complaints of tibia myxedema and eye symptoms were significantly improved after the treatment. Therefore, we should be wary of the occurrence of hyperthyroid-associated EMA syndrome after 131 I therapy. Corticosteroid might be the effective therapy for myxedema and eye symptoms of EMA syndrome.