Expressions and diagnostic value of interleukin-3 1 in tuberculous pleural effusion
10.3760/cma.j.issn.1000-6680.2015.06.002
- VernacularTitle:白细胞介素-31在结核性胸腔积液中的表达水平及其诊断价值
- Author:
Yan GAO
;
Qinfang OU
;
Jing WU
;
Bingyan ZHANG
;
Xinhua WENG
;
Wenhong ZHANG
;
Lingyun SHAO
- Publication Type:Journal Article
- Keywords:
Interleukin-31;
Pleural effusion,malignant;
Tuberculosis,pleural;
Differential diagnosis
- From:
Chinese Journal of Infectious Diseases
2015;(6):323-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of interleukin (IL)-31 in tuberculous pleural effusion,and to evaluate its diagnostic value of tuberculous effusion.Methods Seventy-one patients with pleural effusion were enrolled,including 40 cases of tuberculous pleural effusion and 31 cases of malignant pleural effusion.Luminex method was applied to detect the IL-31 expression in pleural effusion.IL-31 levels were compared using non-parametric Mann-WhitneyU test,and the receiver operator characteristic (ROC)curve was used to elvaluate the diagnostic value of IL-31 .Results IL-31 expression in tuberculous pleural effusion was significantly higher than that in malignant pleural effusion with statistical significance (529.4 ng/L vs 13.8 ng/L,U =62,P <0.01 ).Based on the level of IL-31 expression,area under the ROC curve was 0.95 with the optimum cut-off value of 67.5 ng/L.Thus,the sensitivity and specificity of IL-31 ≥67.5 ng/L for diagnosis of tuberculous pleurisy were 82.5 % (95 %CI :73.3% - 94.2%)and 100.0% (95 %CI :91 .4%-100.0%),respectively.Conclusion IL-31 is highly sensitive and specific for the diagnosis of tuberculous pleural effusion, which favors the differentiation of tuberculosis from malignance.
