Immunotherapy of biliary tract cancer
10.3760/cma.j.issn.1673-422X.2015.08.021
- VernacularTitle:胆道肿瘤的免疫治疗
- Author:
Xiufeng LIU
;
Shukui QIN
- Publication Type:Journal Article
- Keywords:
Biliary tract neoplasms;
Immunotherapy
- From:
Journal of International Oncology
2015;(8):635-637
- CountryChina
- Language:Chinese
-
Abstract:
Biliary tract cancer (BTC)is one of the most aggressive malignancies with only 1 0% early-stage diagnosis rate.For advanced BTC,regimen of gemcitabine and cisplatin has been regarded as the first line standard combination,but the curative effect is still unsatisfied.Infiltration of immune cells and immune-related microenvironment can inhibit various types of cancers.In BTC,higher frequencies of tumor-infiltrating CD8 + cytotoxic T cells and CD4 + T cells are closely associated with favorable prognosis.These findings have provided the rationale for further development of immunotherapies as a novel treatment modality against BTC.
