The protective effect of sufentanil postconditioning on myocardial ischemia-reperfusion injury in rats
10.3969/j.issn.1006-5725.2015.15.009
- VernacularTitle:舒芬太尼后处理对大鼠心肌缺血再灌注损伤的保护作用
- Author:
Yan ZHANG
;
Xinhai WU
;
Fei HUANG
;
Xianghui XU
;
Xiaohui ZHANG
- Publication Type:Journal Article
- Keywords:
Sufentanil;
Pharmacological postconditioning;
Myocardial ischemia reperfusion injury;
PI3K
- From:
The Journal of Practical Medicine
2015;31(15):2440-2442
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of sufentanil postconditioning on myocardial ischemia-reperfusion injury in rats, and to investigate the possible mechanism. Methods Thirty male Sprague-Dawley ratswere randomly divided into 5 groups (n = 6 each): sham group (group S), I/R group (group I/R), low dose of sufentanil postconditioning group (group SL), high dose of sufentanil postconditioning group (group SH) andsufentanil postconditioning plus wortmannin group (group WM). Different drugs were injected before reperfusion: normal saline (NS) and sufentanil 1 μg/kg in group SL, NS and sufentanil 3 μg /kg in group SH, wortmannin 15 μg/kg andsufentanil 1 μg/kgin group WM, and NS in group S and I/R. At the end of reperfusion, artery blood was collected for assessment of plasma cTnI concentration; And the heart was harvested for determination of infarct size (IS) and area at risk (AAR). Results Compared with group S, cTnI concentration was increasedin the rest groups (P< 0.01); Compared with group I/R, cTnI concentration was decreased in group SL, SH and WM, while IS/AAR reduced in group SL and SH (P < 0.01); Compared with group SL, cTnI concentration and IS/AAR were decreased in group SH while increased in group WM (P <0.01). Conclusion Sufentanil postconditioning could attenuate myocardial ischemia-reperfusion injury in rats, and the mechanism involved PI3K related pathway.
