Value of Urinary KIM-1 and NGAL in Predicting the Early Diabetic Nephropathy

VernacularTitle:尿KIM-1和NGAL在糖尿病肾病早期诊断中的应用
Author: Chunlei ZHANG ; Xuehui ZENG ; Zhongxin LI ; Linli SONG ; Shunan ZHANG ; Guibing CHEN
Publication Type:Journal Article
Keywords: diabetic nephropathy; KIM-1; NGAL; biomarkers
From: Journal of Modern Laboratory Medicine 2015;(1):52-54
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of KIM-1 and NGAL in predicting the early diabetes nephropathy(DN).Meth-ods 132 cases of type 1 and type 2 diabetic patients were recruited in this study,patients were divided into four groups based on the urine albumin/creatinine and serum creatinine levels,as follows:normal albuminuria group (45 cases),mi-croalbuminuria group (36 cases),clinical albuminuria group (30 cases),renal failure group (21 cases),65 healthy subjects were recruited as control group.Urinary KIM-1 and NGAL levels were measured by enzyme linked immunosorbent assay (ELISA).Results With the progress of DN,urinary KIM-1 and NGAL levels gradually increased (P<0.05),the urinary KIM-1/Ucr level was positively correlated with ACR (r=0.822,P<0.01),and the urinary NGAL/Ucr was positively cor-related with ACR (r=0.842,P<0.01).Conclusion The urinary KIM-1 and NGAL level can predict the occurrence of ear-ly DN,and also monitor the progression of DN.