The effects of different pacing sites of right ventricle on serum N-terminal Pro brain natriuretic peptide level and left ventricular systolic function
10.3760/cma.j.issn.0254-9026.2015.06.007
- VernacularTitle:右室不同部位起搏对血浆氨基末端脑钠肽前体水平及左心收缩功能的影响
- Author:
Yin REN
;
Li ZHU
;
Zhongbao RUAN
;
Gecai CHEN
;
Junguo ZHU
- Publication Type:Journal Article
- Keywords:
Pacemaker artificial;
Myocardial contraction;
Natriuretic peptide,brain
- From:
Chinese Journal of Geriatrics
2015;34(6):605-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different pacing sites of right ventricle on serum N terminal Pro brain natriuretic peptide (NT-ProBNP) and left ventricular systolic function.Methods A total of 76 patients with an implanted DDD pacemaker were randomly divided into right ventricular septal pacing group (RVSP group,n=40) and right ventricular apex pacing group (RVAP group,n=36) according to the ventricular leads position.Serum NT-proBNP level,left ventricular end diastolic dimension(LVEDD)and left ventricular ejection fraction(LVEF)were analyzed before and 6 months after operation in the two groups.Results There was no difference in serum NT-proBNP level between the two groups before operation,but the serum NT-proBNP level increased in both groups 6 months after operation,and it was higher in RVAP group than in RVSP group (P＜0.05).There were no significant differences in LVEDD and LVEF in RVSP group before and after implantation (P＞0.05).Compared with pre-implantation,LVEDD was increased and LVEF was decreased in RVAP group 6 months after implantation (both P＜0.05).Linear correlation analysis showed that serum NT-proBNP level was negatively correlated to LVEF (2γ=-0.76,P＜0.05).Conclusions Compared with RVAP,RVSP can keep the normal sequence of electrical activity and exert less adverse effects on left ventricular systolic function.Therefore,RVS is an ideal pacing location.
