Application of Polysorbate 80 in Microbial Limit Test
- VernacularTitle:聚山梨酯80在微生物限度检查中的应用
- Author:
Xiangru LIAO
;
Chen CHEN
;
Yang LI
;
Ying CHEN
- Publication Type:Journal Article
- Keywords:
Polysorbate80;
Microbiallimittest;
Testliquid
- From:
China Pharmacist
2014;(10):1776-1777
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To provide appropriate test liquid preparation methods for antibacterial or water-insoluble drugs, and estab-lish a convenient and effective method for microbial limit test. Methods:Using function of polysorbate 80 as neutralization, emulsifica-tion, solubilization and microbial protection, We carried out the liquid preparations were prepared and microbial limit test validation was carried out for 11 kinds of hospital drugs. Results:The bacteria recovery rate and the control bacteria test were in accordance with the requirement of pharmacopoeia. Conclusion:Polysorbate 80 can be used in the microbial limit test of the drugs.
