Brachial-ankle pulse wave velocity correlates to urinaryprotein in patients with type 2 diabetes mellitus
- VernacularTitle:2型糖尿病患者踝肱脉搏波传导速度与尿蛋白的相关性
- Author:
Qianqian ZHANG
;
Pu ZANG
;
Rong JIANG
;
Hong DU
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Brachial-ankle pulse wave velocity;
Urinary protein;
Atherosclerosis
- From:
Journal of Medical Postgraduates
2015;(4):370-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective Urinary protein is closely related to the development and progression of major vascular lesionsin diabetic patients.This study was to investigate the correlation between brachial-ankle pulse wave velocity(baPWV) and urinary protein in patients with type 2 diabetes mellitus ( T2DM) . Methods According to the level of 24-hour urinary albumin ( UAL) , 142 T2DM patients were divided into three groups:control (UA<30 mg, n=84), microalbuminuria(UAL<300 mg, n=26), and clinical albuminuria group ( UAL≥300 mg, n=33) .All the patients underwent examination offasting blood glucose, blood lipid, renal function, HbA1c, islet func-tion, C-reactive protein, blood pressure, and BMI.Their baPWV was determined with an Omron atherosclerosis detector and the correla-tion of baPWV with other factors evaluated by Pearson analysis and multivariate linear regression analysis. Results The baPWVwas significantly higher in themicroalbuminuria([1649.19±229.36]cm/s) and clinical albuminuria ([1759.21±291.05]cm/s) than in the control group ([1522.33±248.37]cm/s) (P<0.05).Pearson analysis showed a positive correlation between 24-hour UAL and baPWV ( r=0.347, P<0.01) and multivariate linear regression analysis manifested the same correlation ( P<0.05) . Conclusion The level of urinary protein is closely correlated with baPWV in T2DM patients.
