Serum cystatin C concentration as an independent marker for hypertensive left ventricular hypertrophy
10.3969/j.issn.1671-5411.2013.03.001
- Author:
Xin LI
;
Hang ZHU
;
Peng LI
;
Qian XIN
;
Jie LIU
;
Wei ZHANG
;
Youhong XING
;
Hao XUE
- Publication Type:Journal Article
- Keywords:
Hypertension;
Left ventricular hypertrophy;
Cystatin C
- From:
Journal of Geriatric Cardiology
2013;(3):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Background Serum cystatin C levels can be used to predict morbidity and mortality in patients with cardiovascular disease. However, the clinical relevance of serum cystatin C levels in patients with hypertensive left ventricular hypertrophy (LVH) has rarely been investigated. We designed the present study to investigate whether serum cystatin C levels are associated with cardiac structural and functional alterations in hypertensive patients. Methods We enrolled 823 hypertensive patients and classified them into two groups:those with LVH (n=287) and those without LVH (n=536). All patients underwent echocardiography and serum cystatin C testing. We analyzed the relationship be-tween serum cystatin C levels and LVH. Results Serum cystatin C levels were higher in hypertensive patients with LVH than in those without LVH (P＜0.05). Using linear correlation analysis, we found a positive correlation between serum cystatin C levels and interven-tricular septal thickness (r=0.247, P＜0.01), posterior wall thickness (r=0.216, P＜0.01), and left ventricular weight index (r=0.347, P＜0.01). When analyzed by multiple linear regression, the positive correlations remained between serum cystatin C and interventricular septal thickness (β=0.167, P＜0.05), posterior wall thickness (β=0.187, P＜0.05), and left ventricular weight index (β=0.245, P＜0.01). Con-clusion Serum cystatin C concentration is an independent marker for hypertensive LVH.
