Analysis of different diagnostic methods for differentiating biliary atresia from hepatitis syndrome
10.3760/cma.j.issn.1673-4408.2014.06.022
- VernacularTitle:胆道闭锁与婴儿肝炎综合征的诊断和鉴别指标的分析
- Author:
Jun CUI
;
Ying HUANG
;
Dajia WANG
;
Pengjun SU
;
Zhibo ZHANG
- Publication Type:Journal Article
- Keywords:
Biliary atresia;
Infant hepatitis syndrome;
Differential diagnosis
- From:
International Journal of Pediatrics
2014;41(6):652-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively evaluate different methods (laboratory tests,liver / gallbladder ultrasound and magnetic resonance cholangiopancreatography)in differentiating biliary atresia from infant hepatitis syndrome.Methods Seventy infants with cholestatic jaundice,50 cases of biliary atresia and 20 cases of infant hepatitis syndrome were studied prospectively from January 2010 to December 2012.All cases underwent abdominal ultrasound and magnetic resonance cholangiopancreatography.The accuracy,sensitivity,specificity and predictive values of these various methods were compared.Also the laboratory parameters were statistically analyzed and compared between groups.Results Patients with BA had significantly higher GGT values at presentation [(743.5 ± 564) IU/L] compared with infants with IHS [(198.8 ± 197.8) IU/L],showing statistically significant difference (P ＜ 0.05).The sensitivity,specificity,and accuracy of the ultrasound in diagnosis of BA were 84.0％ 、100.0％ 、88.6％ respectively(P ＜ 0.05).The values for magnetic resonance cholangiopancreatography were 82.0％ 、80.0％ 、81.4％ (P ＜ 0.05).Conclusion Currently,the method of ultrasound is more reliable than MRCP for differentiating biliary atresia from infant hepatitis syndrome.
