Analysis of molecular characteristics and prognosis in acute myeloid leukemia patients with AML1/ETO
10.3760/cma.j.issn.1009-9921.2015.05.011
- VernacularTitle:AML1/ETO阳性急性髓系白血病的生物学特征及预后分析
- Author:
Junhuang JIANG
;
Suxia LIN
;
Jun YAN
;
Donghui GAN
;
Jinqi HUANG
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,acute;
AML1/ETO;
Prognosis;
Multivariate analysis
- From:
Journal of Leukemia & Lymphoma
2015;24(5):298-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the molecular characteristics and prognosis in acute myeloid leukemia patients with AML1/ETO.Methods The clinical data of 63 cases of acute myeloid leukemia (AML) patients with AML1/ETO positive were analyzed retrospectively.56 cases of AML patients with AML1/ETO negative in the same period were analyzed as control.Characteristics in morphology,immunology,cytogenetics,molecular biology and the clinical effects of treatment were studied and analyzed.Results M2a was 57.12 ％ (36/63),M2b was 33.33 ％ (21/63) in AML with AML1/ETO.The percent of initial marrow blasts was 0.46±0.16.The positive rate of CD34,CD13,CD33,CD19,CD7 and CD56 was 67.21％,52.46 ％,40.98 ％,63.93 ％,4.92 ％ and 50.82 ％,respectively.The rate of t(8;21) translocation was 82.54 ％.There was 4.76 ％ with additional chromosome abnormality,three cases with EV1 1and one case with MLL/AT9.The overall CR rate,the relapse rate,the 3-year and the 5-year overall survival rate was 71.43 ％,51.11％,(43.01±5.31) ％ and (32.79±3.81) ％,respectively.There was no significant difference compared with the control group (P ＞ 0.05).But extramedullary infiltration,the expression of CD56 and additional chromosome abnormality had statistical effects on overall survival (P ＜ 0.05).Conclusions There has unique characteristics in AML with AML1/ETO.The effects of treatment and the prognosis are affected by many factors,so the efficacy and prognosis of AML with AML1/ETO couldn' t just depend on AML1/ETO.
