Analysis of biological features and prognostic factors of mantal cell lymphoma
10.3760/cma.j.issn.1009-9921.2013.09.013
- VernacularTitle:套细胞淋巴瘤生物学特征及预后因素的分析
- Author:
Junlan WANG
;
Qiaohong NIU
;
Qiaohua ZHANG
- Publication Type:Journal Article
- Keywords:
Lymphoma,mantle-cell;
Biological feature;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2013;22(9):552-554
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the biological features and prognostic factors of mantle ceil lymphoma (MCL).Methods The clinical data of 39 cases of MCL were analyzed prospectively.The fellow-up informations were also studied.Age,sex,B symptoms,Ann-Arbor staging,bone marrow and lympho node biopsies were assessed.Serum lactate dehydrogenates(LDH) and β2-microglobulin (β2-MG) level,Cyclin D1 expression and immunophenotype were investigated.Results The median age of patients was 62 years old (range 43-80).The male-to-female ratio was 5.5:1,a clear predominante of male patients.Thirty-five (89.7 ％)cases presented with advanced stage disease (Ann Arbor stage Ⅲ to Ⅳ) at initial diagnosis.CD20 was positive expressed in 39 patients,that all cases expressed B-cell markers.Majority of cases were positive for Cyclin D1 (84.7 ％) and CD5 (64.1％).Conclusion MCL is a special type of B-cell originated non-Hodgkin lymphoma (NHL).The clinical data suggest considerable clinical heterogeneity and it has characteristics of both indolent and aggressive NHL that some patients show a chronic/indolent course,while others have a more fulminant course and short survival.LDH,β2-MG and Cyclin D1 arc the important prognostic factors.
