Allogeneic peripheral blood stem cell transplantation using a low toxicity conditioning regimen with fludarabine and busulfan for 13 patients with hematological malignancies
10.3760/cma.j.issn.1009-9921.2012.06.011
- VernacularTitle:白消安联合氟达拉滨低毒预处理异基因造血干细胞移植治疗恶性血液病13例
- Author:
Yang ZHANG
;
Wanggang ZHANG
;
Jianli WANG
;
Aili HE
;
Xingmei CAO
;
Yinxia CHEN
;
Jie LIU
;
Yun YANG
;
Xiaorong MA
;
Fongxia WANG
;
Pengyu ZHANG
- Publication Type:Journal Article
- Keywords:
Hematologic neoplasms;
Hematopoietic stem cell transplantation;
Transplantation conditioning;
Fludarabine
- From:
Journal of Leukemia & Lymphoma
2012;21(6):360-363
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To discuss the clinical effect of fludarabine and busulfan (Bu+Flu) as a low toxicity myeloablative conditioning regimen for allogeneic peripheral blood stem cell transplantation (allo-HSCT)in leukemia patients.[Methods]Clinical data of 13 patients with hematological malignancies receiving conditioning regimen with Bu+Flu for allo-HSCT were analyzed retrospectively.Conditioning regimen was Bu+Flu,compalriot mismatched and unrelated transplantation combined with rabbit anti-human thymocytes immune globulin (ATG).CsA+short course of methotrexate or CsA + mycophenolate mofetil were used to prevent graft-versus-host disease (GVHD).DNA sequencing of short tandem repeat (STR)polymorphism analysis method was performed for identification of donor stem cells implantation.[Results]13 patients all tolerated with this conditioning regimen well,no serious complications occurred.Neutrophil engraftment was at 9-15 days (median 11 days),platelet engraftment at 8-25 days (median 13 days).10 patients achieved hematopoiesis reconstitution with their full donor chimerisms confirmed by STR-DNA analysis.Acute GVHD occurred in 5 cases,accounting for 38.5％.Chronic GVHD occurred in 4 cases of 10 patients could be assessed,accounting for 40.0％.Severe GVHD more than Ⅱ degree did not happen.1-39 months (median time 11 months)of follow-up revealed the overall survival rate of 76.9％(10/13),disease-free survival of 61.5％ (8/13).The causes for death were relapse in all.[Conclusion]The conditioning regimen with Bu+Flu has low toxicity,well tolerance and better effect.
