Application of high-fluorescence body fluid cell mode on the platform Sysmex XE-5000 automated blood analyzer in diagnosis of meningeal carcinomatosis
10.3969/j.issn.1673-4130.2015.13.017
- VernacularTitle:Sysmex XE-5000全自动血液分析仪高荧光体液细胞计数在脑膜癌诊断中的应用
- Author:
Jiamei CHEN
;
Huiming YE
;
Xiaofen XIAO
;
Yang YU
;
Xianming LIANG
- Publication Type:Journal Article
- Keywords:
meningeal carcinomatosis;
cerebrospinal fluid cytology;
high-fluorescence body fluid cell
- From:
International Journal of Laboratory Medicine
2015;(13):1841-1843
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the performance of high-fluorescence body fluid cell (HF-BF)mode on the platform Sysmex XE-5000 automated blood analyzer,and analyse its clinical application value in diagnosis of meningeal carcinomatosis.Methods E-valuated the performance of HF-BF by using precision test and methodology comparison test.Retrospectively analyzed 295 test re-sults of cerebrospinal fluid in Zhongshan Hospital Affiliated to Xiamen University from June 2010 to September 2012.Results HF-BF on the platform Sysmex XE-5000 automated blood analyzer had high precision,and exhibited a good consistency with cytolgical examination.The percentage of high-fluorescence body fluid cell(HF-BF%)in the meningeal carcinomatosis group was higher than that in other cerebral diseases groups,had statistically significant differences (P < 0.05 ).The cut-off value for HF-BF% was 4.3%,while the area under a receiver operating characteristic (ROC)curve (AUC)was 0.933,the sensitivity was 95.2%,and the specificity was 92.7%.When HF-BF% was over 4.3%,it was more likely to detect tumor cell in cerebrospinal fluid cytology.Con-clusion HF-BF is an effective reference index for the early diagnosis of meningeal carcinomatosis and has significant clinical appli-cation value.
