Correlation between Polymorphisms of GSTM1, GSTT1 and GSTP1 (rs1695) on Hematologic Toxicities with Anthracycline/Paclitaxel-Based Chemotherapy in Breast Cancer
10.3969/j.issn.0253-9896.2014.08.002
- VernacularTitle:GSTM1、GSTT1及GSTP1（rs1695）基因多态性与乳腺癌蒽环和（或）紫杉类药物化疗血液毒性关系的研究
- Author:
Xinlan LIU
;
Yanjiao ZHAO
;
Yin HUANG
;
Min JIANG
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
antineoplastic combined chemotherapy protocols;
glutathione transferase;
polymor-phism,genetic;
polymerase chain reaction;
glutathione S-transferase;
chemotherapy toxicities;
high resolution melting
- From:
Tianjin Medical Journal
2014;(8):741-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effects of genetic polymorphisms in GSTM1, GSTT1 and GSTP1 (rs1695) genes on hematologic toxicities of breast cancer patients receiving Anthracycline/Paclitaxel- based chemotherapy. Methods Multiply PCR technique and High Resolution Melting method were used to examine these 3 genes polymorphsim in female breast cancers (n=252). Results The GSTP1(rs1695) AG/GG genotype was a risk factor forⅢ-Ⅳdegree of neu-trophil toxicity when patients received Paclitaxel-based chemotherapy and Anthracycline-Paclitaxel-based chemotherapy (OR=6.111, 95%CI 1.526-24.469, P<0.05 and OR=9.257, 95%CI 2.903-29.522, P<0.01). There were no statistic differ-ence onⅢ-Ⅳdegree hematologic toxicities rates between GSTM1(+) and GSTM1(-), GSTT1(+) and GSTT1(-) patients after they receiced Paclitaxel-based chemotherapy and Anthracycline-Paclitaxel-based chemotherapy( P>0.05);There was no statistic difference onⅢ-Ⅳdegree hematologic toxicities rates between GSTM1(+) and GSTM1(-), GSTT1(+) and GSTT1(-), GSTP1AA and GSTP1AG/GG patients after they receiced Anthracycline-based chemotherapy (P>0.05). Conclusion The genetic polymorphisms in GSTP1(rs1695) can be used as a gene marker for forecasting the chemotherapy, inducing neutrope-nia toxicities in breast cancer patients receiving Paclitaxel-based chemotherapy.
