Patient-controlled Sedation with Propofol and Alfentanil during Colonofiberscopy.
10.4097/kjae.2004.47.3.321
- Author:
Seung Woo KU
1
;
Ji Yong LEE
;
Sung Lyang CHUNG
;
Gyu Jeong NOH
Author Information
1. Department of Anesthesia and Pain Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. nohgj@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
alfentanil;
lock-out time;
patient-controlled sedation;
propofol
- MeSH:
Alfentanil*;
Blood Pressure;
Germany;
Heart Rate;
Humans;
Incidence;
Pain, Postoperative;
Propofol*;
Respiratory Rate
- From:Korean Journal of Anesthesiology
2004;47(3):321-326
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study was to examine the safety and efficacy of patient-controlled sedation (PCS) according to the lock-out time (LOT, 1 or 2 min) with a demand bolus of propofol and alfentanil fixed during a colonofiberscopy. METHODS: Fifty ASA physical status 1 or 2 patients who underwent a colonofiberscopy were enrolled in this study. They were provided with a PCS pump (Perfusor(R) fm, B Braun Germany, nominal infusion rate, NIR = 1,000 ml/h) containing propofol (9.1 mg/ml) and alfentanil (45.5microgram/ml) in order to self-administer a 2 ml bolus whenever they felt uncomfortable. The lock-out time (LOT) was set to 1 (n = 20, group 1) or 2 (n = 30, group 2) minutes. The Observer's Alertness/Sedation (OAA/S) score, D/A (delivery/attempt, %), blood pressure, heart rate, respiratory rate, SpO2, end tidal CO2 and bispectral index (BIS) were assessed and measured during and/or after the procedures. The verbal descriptive pain scores, as well as the patient's and endoscopist's satisfaction scale were assessed after the procedures. RESULTS: Intraoperative and postoperative pain scores, D/A, the patient's and endoscopist's satisfaction were similar in both groups. However, the lowest BIS values in group 1 was lower than in group 2 (70.3 +/- 12.2 and 77.6 +/- 6.8, respectively, P = 0.010). There were fewer patients whose lowest OAA/S score was <3 in group 2 (4/30) than in group 1 (11/20)(P = 0.002). CONCLUSIONS: With a demand bolus of propofol (18.2 mg) and alfentanil (91.0microgram) fixed, the incidence of over-sedation was higher at LOT 1 min than at LOT 2 min while the efficacy was similar in the PCS with a high NIR during the colonofiberscopy.
