Advances on molecular mechanism of B cell development related with lymphomagenesis in human germinal centres

VernacularTitle:生发中心B细胞发育和淋巴瘤发生的分子机制研究进展
Author: Binshen OUYANG
Publication Type:Journal Article
Keywords: Germinal center; B-lymphocytes; Lymphoma; Molecular mechanisms of action
From: Journal of Leukemia & Lymphoma 2011;20(8):510-512
CountryChina
Language:Chinese
Abstract: Germinal center is a site of B cell maturation and development, in which B cell activation and differentiation was regulated by inherent complexity signal and transcription factors networks. Under the normal condition, the interaction between these transcription factors maintain dynamic stability of B cell in germinal center. When cytogenetic abnormalities or viral infection appear, a variety of.abnormal expression of transcription factors induced the imbalance of B cell signal networks regulation. manifested as abnormal B cell proliferation, apoptosis, and differentiation was blocked. B cell malignancies were often associated with genetic change of B cell and abnormal expression of transcription factors.