Effects of Moxibustion Pretreatment on GSH-Px,SOD and MDA in Gastric Mucosa of Rats with Stress Ulcer
10.1007/s11726-011-0461-0
- VernacularTitle:艾灸预处理对应激性溃疡大鼠胃黏膜GSH-Px,SOD,MDA的影响
- Author:
Mi LIU
;
Xiaorong CHANG
;
Jie YAN
;
Shouxiang YI
;
Yaping LIN
;
Zenghui YUE
;
Yan PENG
;
Xuejun CUI
- Publication Type:Journal Article
- Keywords:
Moxibustion Therapy;
Peptic Ulcer,Glutathione Peroxidase;
Superoxide Dismutase;
Malondialdehyde;
Rats
- From:
Journal of Acupuncture and Tuina Science
2011;09(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of moxibustion pretreatment on Glutathione Peroxidase(GSH-Px),Superoxide Dismutase(SOD),and Malondialchehyche(MDA)in gastric mucosa of rats with stress ulcer,and to investigate the mechanism of moxibustion pretreatment preventing the oxidized injury of gastric mucosa.Methods:Forty-eight healthy SD rats were randomly allocated into 4 groups,namely control group,model group,acupoint moxibustion group,and non-acupoint moxibustion group.The ulcer model was developed by restraint and water immersion stress,Ulcer index(UI)was calculated with Guth method,and the contents of GSH-Px,and MDA and SOD activity in the gastric tissues were measured with chromatometry method.Results:Compared those in the model group and nonacupoint moxibustion group,moxibustion at Zusanli(ST 36)could decrease the UI(P<0.01)and MDA(P<0.05)contents,and increase the activity of GSH-Px(P<0.01)and SOD(P<0.05).Conclusion:Pretreatment of moxibustion at Zusanli(ST 36)could promote the recovery of gastric injury in rats induced by restraint and water immersion stress by enhancing the activity of GSH-Px and SOD,and lower MDA content.
