Murine double minute 2 309 T ＞G polymorphism is associated with gastrointestinal cancer risk especially in Asians: a meta-analysis
10.3760/cma.j.issn.1006-9801.2015.01.012
- VernacularTitle:鼠双微体同源基因2 SNP309多态性与亚洲人群消化道肿瘤遗传易感性研究的Meta分析
- Author:
Wenye MA
;
Ying DONG
;
Zhiqiang CHEN
;
Guanhua WANG
;
Chaoyong TIAN
;
Yanrong WANG
;
Wenjun YANG
- Publication Type:Journal Article
- Keywords:
Murine double minute 2;
SNP309 T＞G;
Gastrointestinal cancer;
Meta-analysis
- From:
Cancer Research and Clinic
2015;27(1):47-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To comprehensively evaluate the relationship between murine double minute 2 (MDM2) gene promoter SNP309 T＞G polymorphism and the susceptibility of gastrointestinal cancer.Methods The China National Knowledge Infrastructure (CNKI),WanFang database,SpringerLink database and PubMed were retrieved to get all case-control research literatures (2005-2012) on the relationship of MDM2 gene SNP309 T＞G and gastrointestinal cancer susceptibility.Meta-analysis with RevMan 4.2 was used to combine OR values of the relationship between SNP309 T＞G and gastrointestinal cancer susceptibility.A sensitivity analysis and tested publication bias were made with all selected literatures' data.Results A total of 17 domestic and foreign qualified papers were included in this study.Twenty case-control studies including 5 183 cases and 6 660 controls were identified for the present meta-analysis.A significant association was detected between the MDM2 SNP309 T＞G polymorphism and gastrointestinal cancer risk.The meta-aualysis showed that the combined odds ratio (OR) for GG genotype was 2.23 (95 ％ CI =1.73-2.89,P ＜ 0.01) compared with that for TG + TT genotypes.There was no statistical significance for the evaluation of publication bias.Conclusion The GG genotype of MDM2 SNP309 may increase gastrointestinal cancer risk in Asians.
