Treatment of relapsed/refractory precursor lymphocytic leukemia/lymphoma by combination of CAG regimen with L-asparaginase and prednisone
10.3760/cma.j.issn.1009-9921.2011.02.009
- VernacularTitle:CAG预激方案联合左旋门冬酰胺酶和泼尼松诱导治疗复发难治性前体淋巴细胞白血病/淋巴瘤
- Author:
Jian ZHOU
;
Baijun FANG
;
Yanli ZHANG
;
Lina ZHANG
;
Yuewen FU
;
Fengkuan YU
;
Yufu LI
;
Xudong WEI
;
Yongping SONG
- Publication Type:Journal Article
- Keywords:
Precursor lymphocytic leukemia/lymphoma;
Recurrence;
Refractory diseases
- From:
Journal of Leukemia & Lymphoma
2011;20(2):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effective treatment with regimen of remission induction for relapsed/refractory precursor lymphocytic leukemia/lymphoma patients. Methods 6 patients with relapsed/refractory precursor lymphocytic leukemia/lymphoma including 2 acute lymphocytic leukemia, 4 lymphoblast lymphoma and 1 hybrid acute leukemia were treated by combination of CAG regimen with L-asparaginase (L-Asp) and prednisone (PDN). Results All patients responded to the regimen, in which 6/7 (85.7 %)patients achieved complete remission and 1/7 (14.3 %) patient achieved partial remission after one course.Light adverse events coursed by the regimen could be tolerated. Conclusion The regimen consisting of CAG, PDN and L-Asp is worth exploring for relapsed/refractory precursor lymphocytic leukemia/lymphoma.
