The Prevalence of Colonic Neoplasm in Cryptogenic Pyogenic Liver Abscess: A Prospectively Enrolled Cross-sectional Study.
10.4166/kjg.2016.68.4.195
- Author:
Nae Yun HEO
1
;
Young Mi HONG
;
Tae Oh KIM
;
Young Soo MOON
;
Sung Yeun YANG
;
Seung Ha PARK
;
Jongha PARK
;
Joon Hyuk CHOI
;
Sung Min KIM
;
Ki Tae YOON
;
Mong CHO
;
Minkyung OH
Author Information
1. Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. kto0440@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Liver abscess, pyogenic;
Colonic neoplasms;
Prevalence
- MeSH:
Abscess;
Adenomatous Polyps;
Colon*;
Colonic Neoplasms*;
Cross-Sectional Studies*;
Drainage;
Gastritis;
Gastrointestinal Microbiome;
Hospitals, University;
Humans;
Klebsiella;
Liver;
Liver Abscess;
Liver Abscess, Pyogenic*;
Male;
Prevalence*;
Prospective Studies*;
Stomach Ulcer;
Ulcer
- From:The Korean Journal of Gastroenterology
2016;68(4):195-201
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Several studies suggest that pyogenic liver abscess (PLA) is associated with colon neoplasm. A colonoscopic exam for cryptogenic PLA might detect a hidden colon neoplasm, through which intestinal flora can be transmitted into the liver. However, there are no prospectively enrolled cross-sectional data for colonic neoplasm in cryptogenic PLA. METHODS: Patients with PLA were prospectively enrolled from two university hospitals. Among them, all the patients with cryptogenic PLA were recommended for colonoscopic exam to check for colonic neoplasm. RESULTS: One hundred eighty-three patients with PLA were enrolled in the study for 22 months. One hundred and one (55.2%) patients did not have a definite cause of liver abscess at initial evaluation. The median diameter of the largest lesion was 5.7 cm (1.0-14.0 cm), and 74.3% of the patients were treated by percutaneous abscess drainage. Ninety-one percent of the patients who had an identified pathogen yielded Klebsiella. Sixty-two patients underwent colonoscopic exams, and no one had a colonic cancer, one had an adenomatous polyp with high grade dysplasia (1.6%), and 27 had adenomatous polyps with low grade dysplasia (43.5%; 41.0% in male and 43.5% in female). Of fifty patients who underwent an esophagogastroduodeno-scopic exam, nine had gastric ulcers, one had an esophageal ulcer, and one had hemorrhagic gastritis. CONCLUSIONS: The prevalence of colonic neoplasm among the patients with cryptogenic PLA was not as high as that in previous studies. Further well-designed, large-scale studies are required to assess the association of the colon neoplasm and cryptogenic PLA.
